Alfalfa Varieties for Ohio

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Psychopathic Personality as a Moderator of the Relationship Between Atypical Sexuality and Sexual Coercion Proclivity in the General Population

Being sexually coerced can have long-lasting psychological impacts on victims; with perpetration strongly predicted by elevated psychopathic traits. Owing to recent legislative developments in the United Kingdom that criminalize coercive control under the Domestic Abuse Act (2021), this study offers a timely investigation into the mechanisms of sexual coercion in domestic abuse across sexual abuse and coercive control. We used moderation analysis (n = 405) to investigate whether sexual coercion proclivity was predicted by facets of atypical sexuality (non-clinical elevated levels of sex drive, sexual sadism, and sexual masochism), and whether this relationship was moderated by psychopathic personality traits specifically the factor one components, which encompasses interpersonal and affective characteristics). Psychopathic personality traits significantly moderated the positive association between sex drive and sexual coercion proclivity, and between sexual sadism and sexual coercion proclivity in males (but not females), but psychopathic personality traits had no such moderating effect in the sexual masochism model. Results are discussed in terms of identifying risk factors of sexual coercion within a general population sample and international application. Open data and a preprint of this paper are available at [https://osf.io/xkcah/?view_only=134ff9c93ad24ba286515b348ce79c0c]

ECONOMIC IMPACTS OF THE COLLEGE OF VETERINARY MEDICINE

Colleges of veterinary medicine are often asked to provide evidence of the economic impacts of their activities. This report presents methods for evaluating a veterinary college and applies them to the Virginia-Maryland Regional College of Veterinary Medicine. Short-run impacts on income and employment are assessed as well as the long-run benefits of the research, extension, teaching, and clinical services of the college.Public Economics,

Trust in Technology: An Empirical Examination of the Construct

In this study, we examine trust in the technology itself. We introduce and distinguish between trusting beliefs, trust in a technology vendor, and willingness to depend on a technology. Empirically, we integrate these constructs into existing innovation diffusion research and examine these constructs’ relationship with the ease of use (EOU), perceived usefulness (PU) and intention to explore technology. Our analysis suggests that (1) trusting belief in technology have a direct effect on EOU and PU, (2) trusting belief in a vendor influenced willingness to depend on a technology and (3) willingness to depend on a technology has a direct effect on PU and a mediated effect on intention to explore. Implications for research and practice are offered

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.

Schistosomiasis affects millions of people in developing countries and is responsible for more than 200,000 deaths annually. Because of toxicity and limited spectrum of activity of alternatives, there is effectively only one drug, praziquantel, available for its treatment. Recent data suggest that drug resistance could soon be a problem. There is therefore the need to identify new drug targets and develop drugs for the treatment of schistosomiasis. Analysis of the Schistosoma mansoni genome sequence for proteins involved in detoxification processes found that it encodes a single cytochrome P450 (CYP450) gene. Here we report that the 1452 bp open reading frame has a characteristic heme-binding region in its catalytic domain with a conserved heme ligating cysteine, a hydrophobic leader sequence present as the membrane interacting region, and overall structural conservation. The highest sequence identity to human CYP450s is 22%. Double stranded RNA (dsRNA) silencing of S. mansoni (Sm)CYP450 in schistosomula results in worm death. Treating larval or adult worms with antifungal azole CYP450 inhibitors results in worm death at low micromolar concentrations. In addition, combinations of SmCYP450-specific dsRNA and miconazole show additive schistosomicidal effects supporting the hypothesis that SmCYP450 is the target of miconazole. Treatment of developing S. mansoni eggs with miconazole results in a dose dependent arrest in embryonic development. Our results indicate that SmCYP450 is essential for worm survival and egg development and validates it as a novel drug target. Preliminary structure-activity relationship suggests that the 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol moiety of miconazole is necessary for activity and that miconazole activity and selectivity could be improved by rational drug design

Moving Beyond Automation: A Framework and Research Agenda Studying the Role of Information Systems in e-HR

Building on Zuboff’s (1985) concepts of the “automating” and “informating” effects of information technology, this study develops a framework that identifies the major areas in which information technology (IT) has the potential to transform the practice and delivery of human resource (HR) management. The framework briefly outlines how a human resource information system (HRIS) assists in the automation of HR processes and supports better information gathering and decision making by managers and HR professionals. Then, using the recruiting function of human resources, the manuscript illustrates how this framework can be used to inform HRIS research and identify gaps in the HRIS literature. This study concludes with a discussion of research questions, which, if examined, will help inform researchers as they study the use of IT to support the firms’ HR function